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866405-64-3|6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶，技术参数

2022-11-04

简介：6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶，Dorsomorphin是一种有效的 ATP 竞争性的选择性 AMPK 抑制剂，Ki 为 109±16 nM。

6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶物理化学性质：

密度

1.3±0.1 g/cm3

分子式

C24H25N5O

分子量

399.488

精确质量

399.205902

PSA

55.55

LogP

2.39

外观性状

固体;White to Yellow to Orange powder to crystal

折射率

1.67

储存条件

0-10°C;存放于惰性气体之中;避免空气,加热

 

6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶详细介绍：

中文名称：

6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶

中文别名：

6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶;6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶;BML-275 抑制剂;Dorsomorphin(化合物C)

英文名称：

Dorsomorphin

英文别名：

6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine;Dorsomorphin;6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;BML-275;Dorsomorphin (Compound C, BML-275);Dorsomorphin dihydrochloride;Pyrazolo[1,5-a]pyrimidine,6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-;AMPK Inhibitor,Compound C;BML275;Compound C;AMPK Inhibitor;AMPK Inhibitor, Compound C;Dorsomorphin (Compound C);4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine;6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine;Dorsomo

CAS号：

866405-64-3

分子式：

C24H25N5O

分子量：

399.49

详细描述：

创赛优选提供866405-64-3，Dorsomorphin (Compound C)，Medlife，上海现货。

Medlife，致力于提供高品质、高性价比小分子化合物的产品。

Medlife小分子化合物大量库存，提供超过2万种的抑制剂、激动剂、拮抗剂等产品，是药物及疾病研究的重要原料供应商。

AMPK抑制剂，Dorsomorphin 是一种有效的 ATP 竞争性的选择性 AMPK 抑制剂，Ki 为 109±16 nM。

查询关键词:“866405-64-3，6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶，Dorsomorphin (Compound C)，PC15481，Medlife，上海现货”。

 

6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶参考文献：

[1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.

[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.

[3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41.

[4]. Chen L, et al. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16;9:761.

货号 产品名称 品牌 规格型号 包装 目录价 促销价 数量 购物车
PC15481 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 Medlife ≥98% 50mg ¥2450.00
PC15481 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 Medlife ≥98% 10mg ¥735.00
PC15481 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 Medlife ≥98% 5mg ¥490.00
PC15481 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 Medlife ≥98% 100mg ¥3586.00
PC15481 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 Medlife ≥98% 200mg ¥5236.00
A03-B3252 [APExBIO]Dorsomorphin (Compound C),98% ,866405-64-3 APExBIO 98% 5mg ¥500.00
A03-B3252 [APExBIO]Dorsomorphin (Compound C),98% ,866405-64-3 APExBIO 98% 10mg ¥750.00
A03-B3252 [APExBIO]Dorsomorphin (Compound C),98% ,866405-64-3 APExBIO 98% 50mg ¥2500.00
PA36820 Dorsomorphin,≥98% ,866405-64-3 PERFEMIKER ≥98% 5mg ¥614.00
PA36820 Dorsomorphin,≥98% ,866405-64-3 PERFEMIKER ≥98% 25mg ¥1978.00
PA36820 Dorsomorphin,≥98% ,866405-64-3 PERFEMIKER ≥98% 100mg ¥4027.00
Sigma-P5499 [Sigma-Aldrich]AMPK抑制剂 ,866405-64-3 Sigma-Aldrich ≥98% (HPLC) 5mg ¥2669.04
Sigma-P5499 [Sigma-Aldrich]AMPK抑制剂 ,866405-64-3 Sigma-Aldrich ≥98% (HPLC) 25MG ¥10655.99
S31490 [源叶]6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶 ,866405-64-3 源叶 ≥98% 5mg ¥500.00
S31490 [源叶]6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶 ,866405-64-3 源叶 ≥98% 25mg ¥1800.00
S31490 [源叶]6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶 ,866405-64-3 源叶 ≥98% 100mg ¥4000.00
D5394 [TCI]Dorsomorphin (LC) ,866405-64-3 TCI ≥97% 10mg ¥940.00
D5394 [TCI]Dorsomorphin (LC) ,866405-64-3 TCI ≥97% 50mg ¥2840.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 5mg ¥89.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 25mg ¥192.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 100mg ¥413.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 500mg ¥1655.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 25mg ¥192.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 100mg ¥413.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 500mg ¥1655.00
MACKLIN-D864421 Dorsomorphin ,866405-64-3 macklin ≥98% 5mg ¥89.00
RHAWN-R032788 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 罗恩 98% 100mg ¥4507.00
RHAWN-R032788 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 罗恩 98% 25mg ¥2321.00
RHAWN-R032788 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 ,866405-64-3 罗恩 98% 5mg ¥642.00
A-D139352 Dorsomorphin ,866405-64-3 Aladdin阿拉丁 ≥98% 25mg ¥1399.00
A-D139352 Dorsomorphin ,866405-64-3 Aladdin阿拉丁 ≥98% 100mg ¥3865.00
A-D139352 Dorsomorphin ,866405-64-3 Aladdin阿拉丁 ≥98% 5mg ¥469.00
A-D276610 Dorsomorphin（化合物C）（DMSO溶液） ,866405-64-3 Aladdin阿拉丁 ≥99% 5mg ¥630.00
TRC-B595893 [TRC]药物标准品Dorsomorphin ,866405-64-3 TRC 25mg ¥3782.00
TRC-B595893 [TRC]药物标准品Dorsomorphin ,866405-64-3 TRC 10mg ¥1891.00
TRC-B595893 [TRC]药物标准品Dorsomorphin ,866405-64-3 TRC 5mg ¥1098.00