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Cy3-UTP(10mM) 抑胃肽酶液 PERFEMIKER AuroraGel 标准型基质胶,不含LDEV
光引发剂LAP 人工胃液 1%柠檬酸钠缓冲液 Salkowskis比色液 人工脑脊液(aCSF,无菌)
1.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸产品物理参数:
2.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸同类产品列表:
3.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸物理化学性质:
4.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸急救措施:
4.1 必要的急救措施描述 一般的建议:请教医生。出示此安全技术说明书给到现场的医生看。 如果吸入:如果吸入,请将患者移到新鲜空气处。如果停止了呼吸,给于人工呼吸。请教医生。 在皮肤接触的情况下:用肥皂和大量的水冲洗。请教医生。 在眼睛接触的情况下:用水冲洗眼睛作为预防措施。 如果误服:切勿给失去知觉者从嘴里喂食任何东西。用水漱口。请教医生。 4.2 最重要的症状和影响,急性的和滞后的 包括了由吞入引起的影响:, 消化系统失调, 血相变化, 可能发生对肝的伤害。 4.3 及时的医疗处理和所需的特殊处理的说明和指示
5.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸消防措施:
5.1 灭火介质 灭火方法及灭火剂 用水雾,耐醇泡沫,干粉或二氧化碳灭火。 5.2 源于此物质或混合物的特别的危害 碳氧化物, 氮氧化物 5.3 救火人员的预防 如必要的话,戴自给式呼吸器去救火。
6.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸泄露应急处理:
6.1 人员的预防,防护设备和紧急处理程序 使用个人防护设备。防止粉尘的生成。防止吸入蒸汽、气雾或气体。保证充分的通风。 避免吸入粉尘。 6.2 环境预防措施 在确保安全的条件下,采取措施防止进一步的泄漏或溢出。不要让产物进入下水道。防止排放到周围环境中。 6.3 抑制和清除溢出物的方法和材料 收集、处理泄漏物,不要产生灰尘。扫掉和铲掉。存放在合适的封闭的处理容器内。
7.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸操作处置与储存:
7.1 安全操作的注意事项 避免接触皮肤和眼睛。 防止粉尘和气溶胶生成。 在有粉尘生成的地方,提供合适的排风设备。一般性的防火保护措施。 7.2 安全储存的条件,包括任何不兼容性 贮存在阴凉处。 容器保持紧闭,储存在干燥通风处。 建议的贮存温度: 2 - 8 °C 充气保存 对湿度敏感
8.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸海关:
9.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸文献:
Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.
Paul W R Harris, Margaret A Brimble
文献索引:Biopolymers 104 , 116-27, (2015)
全文:HTML全文
摘要
The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino acid polypeptide, tagged with an arginine solubilizing tail, was assembled in a convergent manner from four unprotected peptide α-thioester peptide building blocks and one cysteinyl polypeptide, which were in turn prepared by Boc and Fmoc solid phase peptide synthesis (SPPS) respectively. To facilitate the assembly by ligation chemistries, non-native cysteines were introduced as chemical handles into the polypeptide fragments; pseudoproline dipeptides and microwave assisted Fmoc SPPS were crucial techniques to prepare the challenging hydrophobic C-terminal fragment. Three sequential kinetically controlled ligations, which exploited the reactivity between peptide arylthioesters and peptide alkylthioesters, were then used in order to assemble the more tractable N-terminal region of NY-ESO-1. The ensuing 147 residue polypeptide thioester then underwent successful final native chemical ligation with the very hydrophobic C-terminal polypeptide bearing an N-terminal cysteine affording the 186 residue polypeptide as an advanced intermediate en route to the native NY-ESO-1 protein.© 2015 Wiley Periodicals, Inc.
10.N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-L-色氨酸英文别名:
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