103213-32-7|Fmoc-S-三苯甲基-L-半胱氨酸|Fmoc-Cys(Trt)-OH,技术参数

1.Fmoc-S-三苯甲基-L-半胱氨酸产品物理参数：

2.Fmoc-S-三苯甲基-L-半胱氨酸同类产品列表：

3.Fmoc-S-三苯甲基-L-半胱氨酸物理化学性质：

4.Fmoc-S-三苯甲基-L-半胱氨酸急救措施：

4.1 必要的急救措施描述
吸入：如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。
皮肤接触：用肥皂和大量的水冲洗。
眼睛接触：用水冲洗眼睛作为预防措施。
食入：切勿给失去知觉者通过口喂任何东西。 用水漱口。
4.2 主要症状和影响，急性和迟发效应
据我们所知，此化学，物理和毒性性质尚未经完整的研究。
4.3 及时的医疗处理和所需的特殊处理的说明和指示

5.Fmoc-S-三苯甲基-L-半胱氨酸消防措施：

5.1 灭火介质
灭火方法及灭火剂
用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。
5.2 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物, 硫氧化物
5.3 给消防员的建议
如必要的话,戴自给式呼吸器去救火。

6.Fmoc-S-三苯甲基-L-半胱氨酸泄露应急处理：

6.1 作业人员防护措施、防护装备和应急处置程序
避免粉尘生成。 避免吸入蒸气、烟雾或气体。
6.2 环境保护措施
不要让产品进入下水道。
6.3 泄漏化学品的收容、清除方法及所使用的处置材料
扫掉和铲掉。 放入合适的封闭的容器中待处理。

7.Fmoc-S-三苯甲基-L-半胱氨酸操作处置与储存：

7.1 安全操作的注意事项
在有粉尘生成的地方,提供合适的排风设备。
7.2 安全储存的条件,包括任何不兼容性
贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。
建议的贮存温度： 2 - 8 °C
充气保存 对湿度敏感

8.Fmoc-S-三苯甲基-L-半胱氨酸毒性和生态：

Fmoc-S-三苯甲基-L-半胱氨酸生态学数据:

对水稍微危害，避免未稀释或大量的产品接触地下水、水道或污水系统。

若无政府许可，勿将材料排入周围环境。

9.Fmoc-S-三苯甲基-L-半胱氨酸安全信息：

10.Fmoc-S-三苯甲基-L-半胱氨酸海关：

Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.

Stefan Dengl, Eike Hoffmann, Michael Grote, Cornelia Wagner, Olaf Mundigl, Guy Georges, Irmgard Thorey, Kay-Gunnar Stubenrauch, Alexander Bujotzek, Hans-Peter Josel, Sebastian Dziadek, Joerg Benz, Ulrich Brinkmann

文献索引：FASEB J. 29 , 1763-79, (2015)

全文：HTML全文

摘要

Humanized hapten-binding IgGs were designed with an accessible cysteine close to their binding pockets, for specific covalent payload attachment. Individual analyses of known structures of digoxigenin (Dig)- and fluorescein (Fluo) binding antibodies and a new structure of a biotin (Biot)-binder, revealed a "universal" coupling position (52(+2)) in proximity to binding pockets but without contributing to hapten interactions. Payloads that carry a free thiol are positioned on the antibody and covalently linked to it via disulfides. Covalent coupling is achieved and driven toward complete (95-100%) payload occupancy by spontaneous redox shuffling between antibody and payload. Attachment at the universal position works with different haptens, antibodies, and payloads. Examples are the haptens Fluo, Dig, and Biot combined with various fluorescent or peptidic payloads. Disulfide-bonded covalent antibody-payload complexes do not dissociate in vitro and in vivo. Coupling requires the designed cysteine and matching payload thiol because payload or antibody without the Cys/thiol are not linked (<5% nonspecific coupling). Hapten-mediated positioning is necessary as hapten-thiol-payload is only coupled to antibodies that bind matching haptens. Covalent complexes are more stable in vivo than noncovalent counterparts because digoxigeninylated or biotinylated fluorescent payloads without disulfide-linkage are cleared more rapidly in mice (approximately 50% reduced 48 hour serum levels) compared with their covalently linked counterparts. The coupling technology is applicable to many haptens and hapten binding antibodies (confirmed by automated analyses of the structures of 140 additional hapten binding antibodies) and can be applied to modulate the pharmacokinetics of small compounds or peptides. It is also suitable to link payloads in a reduction-releasable manner to tumor- or tissue-targeting delivery vehicles.-Dengl, S., Hoffmann, E., Grote, M., Wagner, C., Mundigl, O., Georges, G., Thorey, I., Stubenrauch, K.-G., Bujotzek, A., Josel, H.-P., Dziadek, S., Benz, J., Brinkmann, U. Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies. © The Author(s).

11.Fmoc-S-三苯甲基-L-半胱氨酸英文别名：