92122-45-7|N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸|Fmoc-D-Lys(Boc)-OH,技术参数

1.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸产品物理参数：

2.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸同类产品列表：

3.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸物理化学性质：

4.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸急救措施：

吸入： 将受害者移到新鲜空气处，保持呼吸通畅，休息。若感不适请求医/就诊。
皮肤接触： 立即去除/脱掉所有被污染的衣物。用水清洗皮肤/淋浴。
若皮肤刺激或发生皮疹：求医/就诊。
眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。继续清洗。
如果眼睛刺激：求医/就诊。
食入： 若感不适，求医/就诊。漱口。
紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。

5.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸消防措施：

合适的灭火剂：干粉，泡沫，雾状水，二氧化碳。
特殊危险性：小心，燃烧或高温下可能分解产生毒烟。
特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。
非相关人员应该撤离至安全地方。
周围一旦着火：如果安全，移去可移动容器。
消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。

6.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸泄漏应急处理：

个人防护措施，防护用具， 使用个人防护用品。远离溢出物/泄露处并处在上风处。
紧急措施：泄露区应该用安全带等圈起来，控制非相关人员进入。
环保措施：防止进入下水道。
控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的法律法规处置。

7.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸操作处置与储存：

处理：
技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手和脸。
注意事项：如果粉尘或浮质产生，使用局部排气。
操作处置注意事项：避免接触皮肤、眼睛和衣物。
贮存：
储存条件：保持容器密闭。冷藏储存。
远离不相容的材料比如氧化剂存放。
热敏
包装材料：依据法律。

8.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸接触控制和个体防护：

① 工程控制：尽可能安装封闭体系或局部排风系统，操作人员切勿直接接触。同时安装淋浴器和洗眼器。
② 个人防护用品：
　呼吸系统防护：防尘面具。依据当地和政府法规。
　手部防护：防护手套。
　眼睛防护：安全防护镜。如果情况需要，佩戴面具。
　皮肤和身体防护：防护服。如果情况需要，穿戴防护靴。

9.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸稳定性和反应性：

化学稳定性：一般情况下稳定。
危险反应的可能性：未报道特殊反应性。
须避免接触的物质氧化剂
危险的分解产物: 一氧化碳, 二氧化碳, 氮氧化物 (NOx)

10.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸废弃处置：

如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中焚烧。废弃处置时请遵守国家、地区和当地的所有法规。

11.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸毒性和生态：

生态学数据：

对水是无危害的，若无政府许可，勿将材料排入周围环境

12.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸海关：

13.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸文献：

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.

Nicholas J Kenyon, Jennifer M Bratt, Joyce Lee, Juntao Luo, Lisa M Franzi, Amir A Zeki, Kit S Lam

文献索引：PLoS ONE 8 , e77730, (2013)

全文：HTML全文

摘要

Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previously developed a well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery of chemotherapeutics agents and, in these studies, we apply this technology for therapeutic development in asthma. In these proof-of-concept experiments, we hypothesized that dexamethasone contained in self-assembling nanoparticles (Dex-NP) and delivered systemically would target the lung and decrease allergic lung inflammation and airways hyper-responsiveness to a greater degree than equivalent doses of dexamethasone (Dex) alone. We found that ovalbumin (Ova)-exposed mice treated with Dex-NP had significantly fewer total cells (2.78 ± 0.44 × 10(5) (n = 18) vs. 5.98 ± 1.3 × 10(5) (n = 13), P<0.05) and eosinophils (1.09 ± 0.28 × 10(5) (n = 18) vs. 2.94 ± 0.6 × 10(5) (n = 12), p<0.05) in the lung lavage than Ova-exposed mice alone. Also, lower levels of the inflammatory cytokines IL-4 (3.43 ± 1.2 (n = 11) vs. 8.56 ± 2.1 (n = 8) pg/ml, p<0.05) and MCP-1 (13.1 ± 3.6 (n = 8) vs. 28.8 ± 8.7 (n = 10) pg/ml, p<0.05) were found in lungs of the Dex-NP compared to control, and they were not lower in the Dex alone group. In addition, respiratory system resistance was lower in the Dex-NP compared to the other Ova-exposed groups suggesting a better therapeutic effect on airways hyperresponsiveness. Taken together, these findings from early-stage drug development studies suggest that the encapsulation and protection of anti-inflammatory agents such as corticosteroids in nanoparticle formulations can improve efficacy. Further development of novel drugs in nanoparticles is warranted to explore potential treatments for chronic inflammatory diseases such as asthma.

14.N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸英文别名：