71989-33-8|FMOC-O-叔丁基-L-丝氨酸|Fmoc-Ser(tBu)-OH,技术参数

1.FMOC-O-叔丁基-L-丝氨酸产品物理参数：

2.FMOC-O-叔丁基-L-丝氨酸同类产品列表：

3.FMOC-O-叔丁基-L-丝氨酸物理化学性质：

4.FMOC-O-叔丁基-L-丝氨酸急救措施：

① 必要的急救措施描述
吸入：如果吸入,请将患者移到新鲜空气处。 如果停止了呼吸,给于人工呼吸。
皮肤接触：用肥皂和大量的水冲洗。
眼睛接触：用水冲洗眼睛作为预防措施。
食入：切勿给失去知觉者从嘴里喂食任何东西。 用水漱口。
② 主要症状和影响，急性和迟发效应
③ 及时的医疗处理和所需的特殊处理的说明和指示

5.FMOC-O-叔丁基-L-丝氨酸消防措施：

① 灭火介质
灭火方法及灭火剂
用水雾,耐醇泡沫,干粉或二氧化碳灭火。
② 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物
③ 给消防员的建议
如必要的话,戴自给式呼吸器去救火。

6.FMOC-O-叔丁基-L-丝氨酸泄露应急处理：

① 人员的预防,防护设备和紧急处理程序
防止粉尘的生成。 防止吸入蒸汽、气雾或气体。
② 环境保护措施
不要让产物进入下水道。
③ 抑制和清除溢出物的方法和材料
扫掉和铲掉。 存放进适当的闭口容器中待处理。

7.FMOC-O-叔丁基-L-丝氨酸操作处置与储存：

① 安全操作的注意事项
在有粉尘生成的地方,提供合适的排风设备。
② 安全储存的条件,包括任何不兼容性
贮存在阴凉处。 容器保持紧闭，储存在干燥通风处。
建议的贮存温度： 2 - 8 °C

8.FMOC-O-叔丁基-L-丝氨酸废弃处置：

废物处理方法：
产品
将剩余的和未回收的溶液交给处理公司。
受污染的容器和包装
作为未用过的产品弃置。

9.FMOC-O-叔丁基-L-丝氨酸毒性和生态：

FMOC-O-叔丁基-L-丝氨酸生态学数据:

通常对水是不危害的，若无政府许可，勿将材料排入周围环境。

10.FMOC-O-叔丁基-L-丝氨酸安全信息：

11.FMOC-O-叔丁基-L-丝氨酸制备：

将O-叔丁基-L-丝氨酸悬浮于二氧六环溶液中，与芴甲氧羰基叠氮进行酰化反应得粗产品，在pH为9-10的条件下用乙酸乙酯抽提，再经重结晶精制而得。

12.FMOC-O-叔丁基-L-丝氨酸海关：

13.FMOC-O-叔丁基-L-丝氨酸文献：

Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.

Stefan Dengl, Eike Hoffmann, Michael Grote, Cornelia Wagner, Olaf Mundigl, Guy Georges, Irmgard Thorey, Kay-Gunnar Stubenrauch, Alexander Bujotzek, Hans-Peter Josel, Sebastian Dziadek, Joerg Benz, Ulrich Brinkmann

文献索引：FASEB J. 29 , 1763-79, (2015)

全文：HTML全文

摘要

Humanized hapten-binding IgGs were designed with an accessible cysteine close to their binding pockets, for specific covalent payload attachment. Individual analyses of known structures of digoxigenin (Dig)- and fluorescein (Fluo) binding antibodies and a new structure of a biotin (Biot)-binder, revealed a "universal" coupling position (52(+2)) in proximity to binding pockets but without contributing to hapten interactions. Payloads that carry a free thiol are positioned on the antibody and covalently linked to it via disulfides. Covalent coupling is achieved and driven toward complete (95-100%) payload occupancy by spontaneous redox shuffling between antibody and payload. Attachment at the universal position works with different haptens, antibodies, and payloads. Examples are the haptens Fluo, Dig, and Biot combined with various fluorescent or peptidic payloads. Disulfide-bonded covalent antibody-payload complexes do not dissociate in vitro and in vivo. Coupling requires the designed cysteine and matching payload thiol because payload or antibody without the Cys/thiol are not linked (<5% nonspecific coupling). Hapten-mediated positioning is necessary as hapten-thiol-payload is only coupled to antibodies that bind matching haptens. Covalent complexes are more stable in vivo than noncovalent counterparts because digoxigeninylated or biotinylated fluorescent payloads without disulfide-linkage are cleared more rapidly in mice (approximately 50% reduced 48 hour serum levels) compared with their covalently linked counterparts. The coupling technology is applicable to many haptens and hapten binding antibodies (confirmed by automated analyses of the structures of 140 additional hapten binding antibodies) and can be applied to modulate the pharmacokinetics of small compounds or peptides. It is also suitable to link payloads in a reduction-releasable manner to tumor- or tissue-targeting delivery vehicles.-Dengl, S., Hoffmann, E., Grote, M., Wagner, C., Mundigl, O., Georges, G., Thorey, I., Stubenrauch, K.-G., Bujotzek, A., Josel, H.-P., Dziadek, S., Benz, J., Brinkmann, U. Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies. © The Author(s).

14.FMOC-O-叔丁基-L-丝氨酸英文别名：