71989-14-5|Fmoc-L-天冬氨酸 beta-叔丁酯|FMOC-ASP(OTBU)-OH,技术参数

1.Fmoc-L-天冬氨酸 beta-叔丁酯产品物理参数：

2.Fmoc-L-天冬氨酸 beta-叔丁酯同类产品列表：

3.Fmoc-L-天冬氨酸 beta-叔丁酯物理化学性质：

4.Fmoc-L-天冬氨酸 beta-叔丁酯急救措施：

① 必要的急救措施描述
吸入：如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。
皮肤接触：用肥皂和大量的水冲洗。
眼睛接触：用水冲洗眼睛作为预防措施。
食入：切勿给失去知觉者通过口喂任何东西。 用水漱口。
② 主要症状和影响，急性和迟发效应
③ 及时的医疗处理和所需的特殊处理的说明和指示

5.Fmoc-L-天冬氨酸 beta-叔丁酯消防措施：

① 灭火介质
灭火方法及灭火剂
用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。
② 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物
③ 给消防员的建议
如必要的话,戴自给式呼吸器去救火。

6.Fmoc-L-天冬氨酸 beta-叔丁酯泄露应急处理：

① 作业人员防护措施、防护装备和应急处置程序
避免粉尘生成。 避免吸入蒸气、烟雾或气体。
② 环境保护措施
不要让产品进入下水道。
③ 泄漏化学品的收容、清除方法及所使用的处置材料
扫掉和铲掉。 放入合适的封闭的容器中待处理。

7.Fmoc-L-天冬氨酸 beta-叔丁酯操作处置与储存：

① 安全操作的注意事项
在有粉尘生成的地方,提供合适的排风设备。
② 安全储存的条件,包括任何不兼容性
贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。
建议的贮存温度： 2 - 8 °C

8.Fmoc-L-天冬氨酸 beta-叔丁酯毒性和生态：

Fmoc-L-天冬氨酸 beta-叔丁酯生态学数据:

通常对水是不危害的，若无政府许可，勿将材料排入周围环境。

9.Fmoc-L-天冬氨酸 beta-叔丁酯安全信息：

10.Fmoc-L-天冬氨酸 beta-叔丁酯海关：

11.Fmoc-L-天冬氨酸 beta-叔丁酯文献：

Evaluation of a nonpeptidic ligand for imaging of cholecystokinin 2 receptor-expressing cancers.

Charity Wayua, Philip S Low

文献索引：J. Nucl. Med. 56(1) , 113-9, (2015)

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摘要

Tumor-specific targeting ligands were recently exploited to deliver both imaging and therapeutic agents selectively to cancer tissues in vivo. Because the cholecystokinin 2 receptor (CCK2R) is overexpressed in various human cancers (e.g., lung, medullary thyroid, pancreatic, colon, and gastrointestinal stromal tumors) but displays limited expression in normal tissues, natural ligands of CCK2R were recently explored for use in the imaging of CCK2R-expressing cancers. Unfortunately, the results from these studies revealed not only that the peptidic CCK2R ligands were unstable in vivo but also that the ligands that mediated good uptake by tumor tissues also promoted a high level of retention of the radioimaging agent in the kidneys, probably because of capture of the conjugates by peptide-scavenging receptors. In an effort to reduce the normal organ retention of CCK2R-targeted drugs, we synthesized a nonpeptidic ligand of CCK2R and examined its specificity for CCK2R both in vitro and in vivo.Nonpeptidic agonists and antagonists of CCK2R described in the literature were evaluated for their affinities and specificities for CCK2R. Z-360, a benzodiazepine-derived CCK2R antagonist with subnanomolar affinity, was selected for complexation to (99m)Tc via multiple spacers. After synthesis and purification, 4 complexes with different physicochemical properties were evaluated for binding to CCK2R-transfected HEK 293 cells. The best conjugate, termed CRL-3-(99m)Tc, was injected into mice bearing CCK2R tumor xenografts and examined by γ scintigraphy and SPECT/CT. The uptake of the conjugate in various organs was also quantified by tissue resection and γ counting.CRL-3-(99m)Tc was shown to bind with low nanomolar affinity to CCK2R in vitro and was localized to tumor tissues in athymic nu/nu mice implanted with CCK2R-expressing tumors. At 4 h after injection, tumor uptake was measured at 12.0 ± 2.0 percentage injected dose per gram of tissue.Because the uptake of CRL-3-(99m)Tc by nonmalignant tissues was negligible and retention in the kidneys was only transient, we suggest that CRL-3-(99m)Tc may be a useful radioimaging agent for the detection, sizing, and monitoring of CCK2R-expressing tumors.© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

12.Fmoc-L-天冬氨酸 beta-叔丁酯英文别名：