1118-89-4|L-谷氨酸二乙酯盐酸盐|H-Glu(OEt)-OEt.HCl，技术参数

L-谷氨酸二乙酯盐酸盐简介：

L-谷氨酸二乙酯盐酸盐是有机合成中间体和医药中间体，可用于实验室研发过程和化工医药合成过程中，主要用于防止癫痫发作或减轻其严重程度的抗惊厥药物。

1.L-谷氨酸二乙酯盐酸盐产品物理参数：

2.L-谷氨酸二乙酯盐酸盐同类产品列表：

3.L-谷氨酸二乙酯盐酸盐用途：

L-谷氨酸二乙酯盐酸盐（1118-89-4）广泛用于医药、食品化妆品行业，营养增补剂，生物生长促进剂。是人体必需氨基酸。

4.L-谷氨酸二乙酯盐酸盐物理化学性质：

5.L-谷氨酸二乙酯盐酸盐急救措施：

① 必要的急救措施描述
如果吸入：
如果吸入,请将患者移到新鲜空气处。 如果停止了呼吸,给于人工呼吸。
在皮肤接触的情况下：
用肥皂和大量的水冲洗。
在眼睛接触的情况下：
用水冲洗眼睛作为预防措施。
如果误服：
切勿给失去知觉者从嘴里喂食任何东西。 用水漱口。
② 最重要的症状和影响，急性的和滞后的
③ 及时的医疗处理和所需的特殊处理的说明和指示

6.L-谷氨酸二乙酯盐酸盐消防措施：

① 灭火介质
灭火方法及灭火剂
用水雾,耐醇泡沫,干粉或二氧化碳灭火。
② 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物, 氯化氢气体
③ 救火人员的预防
如必要的话,戴自给式呼吸器去救火。

7.L-谷氨酸二乙酯盐酸盐泄露应急处理：

① 人员的预防,防护设备和紧急处理程序
防止粉尘的生成。 防止吸入蒸汽、气雾或气体。
② 环境预防措施
不要让产物进入下水道。
③ 抑制和清除溢出物的方法和材料
扫掉和铲掉。 存放在合适的封闭的处理容器内。

8.L-谷氨酸二乙酯盐酸盐毒性和生态：

L-谷氨酸二乙酯盐酸盐毒理学数据:

急性毒性：小鼠引入腹膜LD50：>2gm/kg

9.L-谷氨酸二乙酯盐酸盐安全信息：

10.L-谷氨酸二乙酯盐酸盐海关：

11.L-谷氨酸二乙酯盐酸盐文献：

Fast-acting excitatory amino acids are involved in the enhancement of the aversiveness of the electrical stimulation of the inferior colliculus by systemic injections of muscimol.

Manoel Jorge Nobre, Karina Genaro Borelli, Marcus L Brandão

文献索引：Life Sci. 71(25) , 2961-72, (2002)

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摘要

Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger freezing responses while microinjections of NMDA cause a mixture of immobility and escape responses. Moreover, it has been shown that the neural substrates for defensive behavior in this structure are regulated by GABA-benzodiazepine mechanisms. Indeed, these responses are depressed by muscimol and midazolam locally injected into the inferior colliculus. In this work we were interested in knowing how GABAergic mechanisms interact with the EAA-mediated neural substrates of aversion generated at the inferior colliculus level. We found that while intraperitoneal injections of muscimol caused the expected antiaversive effects, unexpectedly systemic injections of muscimol enhanced the aversive reactions induced by electrical stimulation of the inferior colliculus of rats. Local injections into the central nucleus of the inferior colliculus of GDEE-an AMPA/kainate receptor antagonist-inhibited whereas AP7-a NMDA receptor antagonist-did not influence these responses. It is suggested that systemic injections of muscimol inhibit GABAergic inputs to the inferior colliculus. The removal of these inhibitory influences reduce the well-known tonic inhibitory control exerted by GABAergic mechanisms on the neural substrates of aversion of the inferior colliculus. Activation of these neural substrates by fast-acting AMPA/kainate receptors trigger the initial steps of the defense reaction in the central nucleus of the inferior colliculus.

12.L-谷氨酸二乙酯盐酸盐英文别名：