672-15-1|L-高丝氨酸|L-​Homoserine,技术参数

L-高丝氨酸简介：

L-Homoserine 是一种天然存在的非蛋白丝氨酸，是合成苏氨酸、蛋氨酸和赖氨酸的共有中间体。

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L-高丝氨酸生态学数据:

对水稍微有危害的，不要让未稀释或者大量产品接触地下水，水道或者污水系统。若无政府许可，勿将材料排入周围环境。

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8.L-高丝氨酸文献：

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Arun Sreekumar, Laila M Poisson, Thekkelnaycke M Rajendiran, Amjad P Khan, Qi Cao, Jindan Yu, Bharathi Laxman, Rohit Mehra, Robert J Lonigro, Yong Li, Mukesh K Nyati, Aarif Ahsan, Shanker Kalyana-Sundaram, Bo Han, Xuhong Cao, Jaeman Byun, Gilbert S Omenn, Debashis Ghosh, Subramaniam Pennathur, Danny C Alexander, Alvin Berger, Jeffrey R Shuster, John T Wei, Sooryanarayana Varambally, Christopher Beecher, Arul M Chinnaiyan

文献索引：Nature 457(7231) , 910-4, (2009)

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摘要

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have been extensively profiled in human tumours, little is known about the global metabolomic alterations that characterize neoplastic progression. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we profiled more than 1,126 metabolites across 262 clinical samples related to prostate cancer (42 tissues and 110 each of urine and plasma). These unbiased metabolomic profiles were able to distinguish benign prostate, clinically localized prostate cancer and metastatic disease. Sarcosine, an N-methyl derivative of the amino acid glycine, was identified as a differential metabolite that was highly increased during prostate cancer progression to metastasis and can be detected non-invasively in urine. Sarcosine levels were also increased in invasive prostate cancer cell lines relative to benign prostate epithelial cells. Knockdown of glycine-N-methyl transferase, the enzyme that generates sarcosine from glycine, attenuated prostate cancer invasion. Addition of exogenous sarcosine or knockdown of the enzyme that leads to sarcosine degradation, sarcosine dehydrogenase, induced an invasive phenotype in benign prostate epithelial cells. Androgen receptor and the ERG gene fusion product coordinately regulate components of the sarcosine pathway. Here, by profiling the metabolomic alterations of prostate cancer progression, we reveal sarcosine as a potentially important metabolic intermediary of cancer cell invasion and aggressivity.

9.L-高丝氨酸英文别名：

Homoserine、(2S)-2-Amino-4-hydroxybutyric Acid、H-HOMOSERINE、(S)-2-amino-4-hydroxy-Butanoic acid、H-HSE-OH、(S)-Homoserine、HOMOSERINE-L、MFCD00063090